General Manager (GM) Question:

This really depends on what my co-worker is doing, the severity of their actions and the specific problems or disruption that they may be causing. Having said that no matter what the situation is, I would always remain in control of any situation and concentrate on my work. I would not take any arguments or heated discussions personally or hold grudges against work colleagues.
I would avoid them and only talk to them or cooperate with them when required to in the course of my daily duties.