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Pharma Exam frequently Asked Questions by expert members with experience in pharmaceutical Exam. These interview questions and answers on Pharma Exam will help you strengthen your technical skills, prepare for the interviews and quickly revise the concepts. So get preparation for the Pharma Exam job interview
47 Pharma Exam Questions and Answers:
Table of Contents:
1 :: What drug(s) inhibit the second stage of the cell wall synthesis? (Precursor transported from inside cell membrane to outside)
Vancomycin and Bacitracin
2 :: What drug(s) inhibit the third stage of the cell wall synthesis? (Cross linking of the cell wall)?
Penicillin and Cephalosporin
3 :: What does Cell Death require?
Action of Autolysin
4 :: What are three mechanisms of resistance to Penicillin?
Lack of accessibility to target (Gram Negative)
Production of Penicillinases (Beta-Lactamase)
Alterations in Penicillin Binding Proteins
Production of Penicillinases (Beta-Lactamase)
Alterations in Penicillin Binding Proteins
7 :: Is oral use of Penicillin G indicated?
Not, it is inactivated at low pH
10 :: Which type of penicillin is acid stable?
Penicillin V
11 :: Should you use sulfonamides on a patient with 6-glucose phosphate dehydrogenase deficiency?
No, it could produce acute hemolytic anemia
13 :: Why are long-acting sulfonamides not available in the US any longer?
Due to the high incidence of Stevens-Johnson syndrome
14 :: What is the mechanism of Trimethoprim?
It is a selective inhibitor of Dihydrofolate reductase
16 :: Which types of bacteria are targeted by Trimethoprim?
Both Gram - and Gram +
Its Broad Spectrum
Its Broad Spectrum
17 :: Which chemotherapeutic agents are inhibitors of cell wall synthesis?
Penicillin
Cephalosporin
Vancomycin
Bacitracin
Cycloserine
Cephalosporin
Vancomycin
Bacitracin
Cycloserine
20 :: What log cell kill is required to cure microbial infections?
2 (99% of population is killed)
22 :: What types of bacteria do sulfonamides target?
Broad-Spectrum - Gram + and Gram -
23 :: What is the mechanism of action of sulfonamides?
They are structural analogs and competitive antagonists of PABA (Para-Aminobenzoic Acid)
25 :: How do sulfonamides not interfere with host metabolism?
Mammalian cells use preformed folic acid.
