Pharma Exam Question:
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What are six mechanisms of resistance from chemotherapeutic agents?
Answer:
1) Absence of Target (Ergosterol's absent)
2) Alterations in Target (Pen. Binding Protein Alterations)
3) Low concentration at target (Interference with membrane passage)
4) Lack of metabolic activation (Antifungal Flucytosine -> Fluorouracil)
5) Inactivation (Penicillinases)
6) Escape from Effect (Alternate Metabolic Pathways)
2) Alterations in Target (Pen. Binding Protein Alterations)
3) Low concentration at target (Interference with membrane passage)
4) Lack of metabolic activation (Antifungal Flucytosine -> Fluorouracil)
5) Inactivation (Penicillinases)
6) Escape from Effect (Alternate Metabolic Pathways)
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