Pathology Interview Preparation Guide
Pathology Interview Questions and Answers will guide us now that Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and study of the whole bodies autopsies. Learn basic and advance concepts of the Pathology or get preparation of Pathology jobs interview with our Pathology Interview Questions and Answers Guide.166 Pathology Questions and Answers:
1 :: What is a "gene expression signature" for a tumor?
A collection of genes that are expressed consistently higher or lower in the tumor than is the population norm for non-tumorous tissue of the same type.
2 :: What are the benefits of high-throughput expression analysis in molecular biological investigations?
These techniques allow simultaneous analysis of the expression of many genes. Patterns of increased or decreased expression is associated with disease may then be identified and may contribute to improved diagnosis and prognosis.
3 :: To what 2 aspects of a usability assessment should the word "representative" apply?
(1) Representative tasks
(2) Representative users
(2) Representative users
4 :: Dr Jones is a pathologist who has recently developed a virtual microscope program for teenagers to use while they are hospitalized. He thinks that teens might use this program to learn more about their illness and the role that pathology plays in the hospital. He has heard that usability is important, so he asks a few of his colleagues to try the program out in their free time and to e-mail their comments to him. Describe 3 specific things that Dr Jones should have done differently in order; to more appropriately assess the usability of his program.
(1) Have teens test the program, not physicians;
(2) select specific representative tasks for the assessment (not just "try the program out"); and
(3) observe the participants using the program and have them think aloud during the session rather than e-mail comments.
(2) select specific representative tasks for the assessment (not just "try the program out"); and
(3) observe the participants using the program and have them think aloud during the session rather than e-mail comments.
5 :: There are about 40 000 human genes and ESTs (expressed sequence tags) available on the Affymetrix Gene Chips for gene expression. Make some reasonable assumptions and estimate, for a normal organ, the number of genes that will appear to be expressed significantly greater than or less than the population norm (95% confidence interval).
If we assume that each gene is independent and occurs in a normally distributed population, then one might expect approximately 5% of 40 000 or 2000 genes to appear over expressed or under expressed.