Answer:
JSONP is universally supported on just about every browser and a lot of useful APIs have support for it already in place (Yahoo, Twitter, Google, etc.) Aside from the regular XMLHttpRequest and DOM differences, nothing really special needs to be done to make it work across different browsers. Finally, since it has been around for a bit, there are pretty mature JSONP plugins for just about every major library and framework around (JQuery, YUI, Prototype, etc.)
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