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A condition in which there is a shift in the acid-base balance of the body to have more acid than normal, often causing the pH of the blood and body tissues to fall below the healthy range (7.35-7.45). It may be caused by decreased CO2 eliimination in respiratory disorders such as emphysema, by metabolic problems such as kidney disease and diabetes, or as the result of ingesting poisons (ethlylene glycol, methanol) or overdosing on certain medication (salicylates); it can also be caused by losing HCO3, as in diarrhea.